Agranulocytosis is a condition characterized by reduced number of Granulocytes. Granulocytes are a type of white blood cells that are responsible for healthy immunity. Granulocytes are filled with microscopic granules that contain enzymes which digest microorganisms. Granulocytes are made in bone marrow and it travels the whole body through blood. When the numbers of granulocytes are drastically reduced within the body, leaving them too few in numbers, the resulting condition is called ‘Agranulocytosis’.

Alternate names

Granulocytopenia, Granulopenia


Since Agranulocytosis is a condition where immunity decreases, the possibility of an infection to occur increases dramatically. The symptoms of Agranulocytosis are usually the symptoms of infection. However, in absence of any infection, Agranulocytosis can be asymptomatic.

  • Sore throat
  • Chills
  • Sudden fever
  • Weakness in limbs
  • Mouth ulcers
  • Bleeding gums
  • Sore mouth
  • Fast heart rate
  • Low blood pressure
  • Sore gums
  • Skin abscesses
  • Rapid breathing
  • Rapid progression of infection of any organ
  • Rapid progression of Septicemia


  • Street drugs
  • Autoimmune disorders
  • Genetic problems
  • Poor nutrition
  • Preparation for bone marrow transplant
  • Antiepileptic drugs
  • Anti-thyroid drugs like carbimazole, methimazole, propylthiouracil
  • Antibiotics like penicillin, chloramphenicol, cotrimoxazole
  • ACE inhibitors like benazepril
  • Anti-cancer drugs
  • Pain killers (NSAIDs) like indomethacin, naproxen, phenylbutazone, metamizole
  • Anti-depressant drugs
  • Anti-psychotic drugs


  • A blood test with differential WBC count is done to find out the percentage of each type of WBCs.


  • Treatment of Agranulocytosis depends on the cause. For example, if a drug/medicine is causing it, discontinuation of the drug is required. Shifting patient on a nutrition rich diet if the cause is poor nutrition may help. Discontinuation of the drug that causes bone marrow depression may help.
  • In severe cases of Agranulocytosis, transfusion of granulocytes can also be considered.


  • Exercise precaution and observe for the symptoms if you are taking any medicine that is known to cause Agranulocytosis.
  • Consult your doctor as soon as possible if you observe any symptoms associated with Agranulocytosis.
  • Take a nutrition rich diet if you are taking any medicines that are known to cause Agranulocytosis.

Click here to go to Agranulocytosis forums

Evaluation of parenterals

October 12th, 2018|0 Comments

The following tests are performed on the finished [arenteral products to maintain quality control: Leakage test Clarity test Pyrogen test Sterility test Evaluation of Parenterals or quality control tests of the parenteral products [...]

  • advance directives

advance directive

September 5th, 2018|0 Comments

Advance directives Contents of the post Overview Other names Types of advance directives The need for a living will Important aspects related to a durable power of attorney for a health care Living will [...]

  • Is omeprazole addictive

Is omeprazole addictive

August 28th, 2018|0 Comments

Is omeprazole addictive? Is Omeprazole addictive? Contents of the post Indications Examples of PPI's (Proton Pump Inhibitors) Purpose of recommending or prescribing or consuming omeprazole or any other PPI Is omeprazole and other [...]

  • copd


August 9th, 2018|0 Comments

COPD (Chronic Obstructive Pulmonary Disease) Index of the post Introduction Some numbers and facts on COPD Causes Risk factors Symptoms Diagnosis Treatment Treatment of symptoms Treatment of flare-ups Oxygen therapy Pulmonary rehabilitation Other [...]

  • pulmonary embolism

Pulmonary embolism

August 6th, 2018|0 Comments

Pulmonary embolism Contents of the post Overview Causes Symptoms Diagnosis Prevention Treatment Prognosis Factors which predisposes a person  to blood clots References and further reading Overview Pulmonary embolism is the sudden blocking of an [...]

  • atelectasis vs bronchiectasis

atelectasis vs bronchiectasis

July 30th, 2018|0 Comments

atelectasis vs bronchiectasis Atelectasis Atelectasis is a condition in which all or part of a lung becomes airless and contracts. It may be acute or chronic. Bronchiectasis [...]

By |2017-12-21T10:07:08+00:00April 21st, 2017|Disease/pathological condition|0 Comments

About the Author:

B. Pharm (K.L.E. society's S.V.V. Patil College of Pharmacy, Bengaluru) M. Pharm (Maharishi Arvind Institute of Pharmacy, Jaipur)

Leave A Comment


In today's fast paced life, we often come across minor health issues that we often neglect due to lack of time for paying a visit to a doctor, which usually takes away 2-3 hours of a person's time and are expensive too. Further more, such minor conditions may grow big at any time if neglected. Our aim in setting up this platform is that any person can search for any health condition or medicines and can get all the needed information within hardly 10-15 minutes, which saves a lot of time and money. After going through every information, if the person has any questions, he/she can go to our forums section and raise a topic. This will help him/her decide better whether he/she needs to pay an immediate visit to a doctor or can it wait for a day or two? Help us in bringing awareness about diseases and medicines by spreading the word to at least 5 of your friends and relatives.
Select your currency