agranulocytosis

Agranulocytosis

Agranulocytosis is a condition characterized by reduced number of Granulocytes. Granulocytes are a type of white blood cells that are responsible for healthy immunity. Granulocytes are filled with microscopic granules that contain enzymes which digest microorganisms. Granulocytes are made in bone marrow and it travels the whole body through blood. When the numbers of granulocytes are drastically reduced within the body, leaving them too few in numbers, the resulting condition is called ‘Agranulocytosis’.

Alternate names

Granulocytopenia, Granulopenia

Symptoms

Since Agranulocytosis is a condition where immunity decreases, the possibility of an infection to occur increases dramatically. The symptoms of Agranulocytosis are usually the symptoms of infection. However, in absence of any infection, Agranulocytosis can be asymptomatic.

  • Sore throat
  • Chills
  • Sudden fever
  • Weakness in limbs
  • Mouth ulcers
  • Bleeding gums
  • Sore mouth
  • Fast heart rate
  • Low blood pressure
  • Sore gums
  • Skin abscesses
  • Rapid breathing
  • Rapid progression of infection of any organ
  • Rapid progression of Septicemia

Causes

  • Street drugs
  • Autoimmune disorders
  • Genetic problems
  • Poor nutrition
  • Preparation for bone marrow transplant
  • Antiepileptic drugs
  • Anti-thyroid drugs like carbimazole, methimazole, propylthiouracil
  • Antibiotics like penicillin, chloramphenicol, cotrimoxazole
  • ACE inhibitors like benazepril
  • Anti-cancer drugs
  • Pain killers (NSAIDs) like indomethacin, naproxen, phenylbutazone, metamizole
  • Anti-depressant drugs
  • Anti-psychotic drugs

Diagnosis

  • A blood test with differential WBC count is done to find out the percentage of each type of WBCs.

Treatment

  • Treatment of Agranulocytosis depends on the cause. For example, if a drug/medicine is causing it, discontinuation of the drug is required. Shifting patient on a nutrition rich diet if the cause is poor nutrition may help. Discontinuation of the drug that causes bone marrow depression may help.
  • In severe cases of Agranulocytosis, transfusion of granulocytes can also be considered.

Precautions

  • Exercise precaution and observe for the symptoms if you are taking any medicine that is known to cause Agranulocytosis.
  • Consult your doctor as soon as possible if you observe any symptoms associated with Agranulocytosis.
  • Take a nutrition rich diet if you are taking any medicines that are known to cause Agranulocytosis.

Click here to go to Agranulocytosis forums

  • gpat mock test

GPAT mock test – 1

November 21st, 2017|0 Comments

GPAT mock test #1 Questions Answers to this questions are given at the end of the test. please refer and calculate your score. In sugar coating, seal coat is done: To prevent [...]

  • abnormal vaginal bleeding

Abnormal vaginal bleeding

November 1st, 2017|0 Comments

Abnormal vaginal bleeding During reproductive years, bleeding from the vagina may be abnormal when menstrual periods are too heavy or too light, last too long, occur too frequently, or are irregular. Any vaginal bleeding [...]

  • Occupational lung diseases

Occupational lung diseases

September 19th, 2017|1 Comment

Occupational lung diseases Occupational lung diseases are caused by harmful particles, mists, vapors or gases that are inhaled, usually while a person works. If the lung disease is due to inhaled particles, the term pneumoconiosis [...]

  • silicosis

Silicosis

September 12th, 2017|0 Comments

Silicosis Complete information on asbestosis including symptoms, diagnosis, prevention and treatment for patient, professional and student use Silicosis is the permanent scaring of the lungs caused by inhaling silica (quartz) dust. Silicosis is the oldest [...]

  • Occupational asthma

Occupational asthma

September 12th, 2017|0 Comments

Occupational asthma  Complete information on asbestosis including symptoms, diagnosis, prevention and treatment for patient, professional and student use Occupational asthma is a reversible narrowing of the airways caused by inhaling work-related particles or vapors that [...]

  • Byssinosis

Byssinosis

September 12th, 2017|0 Comments

Byssinosis Complete information on asbestosis including symptoms, diagnosis, prevention and treatment for patient, professional and student use Byssinosis is a narrowing of the airways caused by inhaling cotton flax or hemp particles. In the US [...]

By | 2017-04-26T17:29:44+00:00 April 21st, 2017|Disease/pathological condition|0 Comments

About the Author:

B. Pharm (K.L.E. society’s S.V.V. Patil College of Pharmacy, Bengaluru)
M. Pharm (Maharishi Arvind Institute of Pharmacy, Jaipur)

Leave A Comment

CommentLuv badge

WE NEED YOUR HELP IN CREATING AWARENESS ABOUT DISEASES AND MEDICINES

In today's fast paced life, we often come across minor health issues that we often neglect due to lack of time for paying a visit to a doctor, which usually takes away 2-3 hours of a person's time and are expensive too. Further more, such minor conditions may grow big at any time if neglected. Our aim in setting up this platform is that any person can search for any health condition or medicines and can get all the needed information within hardly 10-15 minutes, which saves a lot of time and money. After going through every information, if the person has any questions, he/she can go to our forums section and raise a topic. This will help him/her decide better whether he/she needs to pay an immediate visit to a doctor or can it wait for a day or two? Help us in bringing awareness about diseases and medicines by spreading the word to at least 5 of your friends and relatives.

To pay with credit card or debit card, Checkout with paypal. On the next page you will find links for credit/debit card payments. Dismiss