Complete information including dosage, side effects, interactions, pregnancy & breast feeding warnings for patient and professional use.
Overview and uses
Delavirdine is a medicine used for HIV treatment. It is available only as a prescription medicine. Delavirdine is prescribed by a doctor in combination with other medicines for HIV treatment. This is done to increase the therapeutic efficacy of the medicines used in the treatment of HIV. Also, combination therapy reduces the risk of virus getting resistant to any one particular medicine.
Delavirdine does not cure HIV, but it slows down the progression of HIV within the body. HIV destroys CD4+ T Lymphocytes – a type of white blood cells (WBC) that gives immunity to the body. In other words, these cells protect the body against the infections or illness caused by various organisms like bacteria, viruses and other germs. Thus, one may conclude that HIV infection, if left untreated, may make the body susceptible to this infections/illness.
Brand names: Rescriptor.
Pharmacological classification: Nonnuucleoside reverse transcriptase inhibitor anti-retroviral drug
Mechanism of action: Delavirdine directly inhibits the HIV reverse transcriptase and terminates the elongation of proviral DNA.
Indication (used for):
- For the treatment of HIV-1 infections in combination with at least 2 other anti HIV medicines.
Data not available for patients less than 16 years of age and more than 65 years of age.
- Adult dose:
- 200 mg twice a day after meals.
- Pediatric dose (based on body weight) for children with 6 years or more of age:
- 16 kg or more but less than 20 kg: 100 mg twice a day.
- 20 kg or more but less than 25 kg: 125 mg twice a day.
- 25 kg or more but less than 30 kg: 150 mg twice a day.
- 30 kg or more: 200 mg twice a day.
Dosage form: Delavirdine is available as tablets in strength of 25 mg, 50 mg and 100 mg.
- No known antidote for Emtricitabine overdose.
- Overdose of Efavirenz may lead to increased nervous system symptoms.
- Standard supportive treatment should be applied as and when necessary.
- Activated charcoal may be used to remove any unabsorbed drug.
- Efavirenz is highly unlikely to remove by dialysis as it is highly protein bound.
- Avoid meals that are high in fat.
Unwanted or side effects:
- Severe skin and hypersensitivity reactions have been reported.
- Consult your doctor as soon as possible if a rash occurs.
- Occurrence of life threatening Stevens-Johnson syndrome is rare.
- Seek medical attention as soon as possible by contacting emergency department of local hospital as this condition is life threatening.
- Fat redistribution or accumulation of body fat including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement and “cushingoid appearance” have been observed in patients receiving anti HIV therapy.
- Immune reconstitution syndrome: during the initial phase of the treatment, patients whose immune systems respond may develop an inflammatory response to opportunistic infections, which may necessitate further evaluation and treatment. Auto immune disorders have also been reported to occur in some people at any time after the initiation of the treatment.
Contraindications of Delavirdine:
Category B, which means that Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
- Data not available for
- In general, it is advisable that mothers don’t breast feed their children to avoid post-natal transmission of HIV.
Drug – drug interactions:
- Delavirdine increases the concentration of Rifabutin, nelfinavir, Saquinavir and clarithromycin.
- Delavirdine decreases the concentration of Indinavir and Didanosine.
- Delavirdine does not affect Zidovudine concentrations.
- Clarithromycin, sulfomethoxazole, Saquinavir, Zidovudine, Indinavir and fluconazole does not affect the concentration of Delavirdine.
- Rifabutin, rifampin, nelfinavir, Didanosine, phenytoin, phenobarbital and carbamazepine reduces the concentration of Delavirdine.
Drug – food interactions:
- Food increases the AUC of Delavirdine by 50%.
Important information on anti HIV and anti AIDS medicines
Benefits of taking your anti HIV medicines regularly
- Sustained viral suppression.
- Reduced risk of resistance.
- Reduced risk of treatment failure.
- Improved quality of life and overall health.
- Reduced risk of HIV transmission.
Getting the most from your treatment
- Precisely follow every advice given to you by your doctor and pharmacist regarding your medications. Take your dose regularly without missing out a single one.
- Make all the necessary changes in your lifestyle and eating/food habits as advised by your doctor and pharmacist. This may include quitting smoking, alcohol, other substances of abuse, taking up exercise and some/many others that your doctor finds it best in your interest.
- Do not make any changes in your dose unless suggested/recommended by your doctor.
- Keep your regular appointments with your doctor so that the progress can be monitored. This may involve blood tests and other test that a doctor finds necessary.
- Consult your doctor if you develop an infection or an allergy after you start the treatment.
- Consult your doctor if you feel low or even depressed. This is common especially after diagnosis and during the early stages of treatment.
- Some people who have taken anti HIV medicines for a long period of time may develop Osteonecrosis – a condition where bone tissue dies due to reduced blood supply. This causes joint pain, stiffness and difficulty in movement. Consult your doctor if you if you notice any of this symptoms.
- If you are going to take any operation/surgery or a dental treatment, tell doctor who is going to carry out operation/surgery or dental procedure about all the medicines that you are taking. If possible, carry your containers with you to the doctor even if it is empty.
- If you buy any medicines, supplements including your vitamin supplements, herbal medicines or even the medicines that do not require a prescription, check with your pharmacist whether they can be taken along with your anti HIV medicines or not.
- Treatment of HIV is life-long. Continue taking your anti HIV medicines even if you feel well. This should be done to keep your immune system healthy.
Forgot to take your medicine?
- Forgetting a dose/frequent missed out doses may lead to viral resistance or treatment failure.
- If you forget to take a dose, take it immediately as soon as you remember unless it’s almost the time for your next dose.
- Do not take two doses at the same time to make up for the missed out dose.
- If you are forgetting/missing your dose frequently or very often, try using pill boxes that are available as weekly or monthly dose boxes. Alternatively, you can also try posting reminder notes on places like doors of refrigerator, wardrobe, bathroom, side tables of your bed, above or below switch boards etc. You can also set a reminder on your cell phone.
- If possible, ask your family members and friends to remind you of your dose.
Click here to go to Delavirdine forums
Note: The sole purpose of every information shared on this article is to bring awareness. Do not use this information as a medical advice or prescription advice or as a tool for the treatment, diagnosis or prevention of the disease.