Lansoprazole

LANSOPRAZOLE

Complete information including dosage, side effects, interactions and pregnancy & breast feeding warnings for Patients and Healthcare professionals

Overview & uses

Lansoprazole is a drug used to reduce the amount of acid secreted in stomach.

Indication (uses):

  • For short term treatment of active duodenal ulcers.
  • For the maintenance of healed duodenal ulcers.
  • Short term treatment of active benign gastric ulcers.
  • For the healing of gastric ulcers associated with NSAID.
  • For the reduction in the occurrence of gastric ulcers associated with NSAID therapy.
  • For the treatment of symptoms of Gastroesophageal Reflux Disease (GERD), for both erosive esophagitis and symptomatic GERD.
  • For the treatment of Pathological Hypersecretory Conditions including Zollinger-Ellison syndrome.
  • For the eradication of H. pylori to reduce the risk of duodenal ulcer recurrence.
    • As a triple therapy in combination with amoxicillin and clarithromycin.
    • As a double therapy in combination with amoxicillin.
  • For the maintenance of the healing of Erosive esophagitis.

Pharmacological classification: Proton pump inhibitor for the reduction of gastric acid secretion

Brand names: Prevacid, Prevacid solutab

Dosage form:

  • Delayed release capsules in strengths of 15 mg and 30 mg for oral use.
  • Delayed release orally disintegrating tablets (solutab) for oral use in strengths of 15 mg and 30 mg.

Mechanism of action:

All proton pump inhibitors are inactive at neutral pH. But, as soon as pH drops below 5, the drug rearranges into two positively charged ions and binds with H+K+ATPase enzyme by forming a covalent bond and inactivates the enzyme. It also inhibits the mucosal carbonic anhydrase enzyme.

Dosage

How to take Lansoprazole tablets (solutab) or capsules?

  • Lansoprazole capsules can be taken on empty stomach before meals.
  • Lansoprazole tablets (solutab) and capsules should be swallowed whole and should not be chewed, crushed or spit.

Dosage (for adult patients):

  • For short term treatment of duodenal ulcers:
    • 15 mg once a day for 4 weeks.
  • For the maintenance of healed duodenal ulcers:
    • 15 mg once a day.
  • For the eradication of pylori to reduce the risk of duodenal ulcer recurrence:
    • Lansoprazole 30 mg twice a day with amoxicillin 1000 mg twice a day and clarithromycin 500 mg twice a day for 10 or 14 days.
    • Lansoprazole 30 mg three times a day with amoxicillin 1000 mg thrice a day for 14 days.
  • For short term treatment of benign gastric ulcer:
    • 30 mg once a day for up to 8 weeks.
  • For the healing of NSAID associated gastric ulcer:
    • 30 mg once a day for 8 weeks.
  • For reduction in risk of occurrence of gastric ulcer associated with NSAID treatment:
    • 15 mg once a day for up to 12 weeks.
  • For short term treatment of symptoms of GERD:
    • 15 mg once a day for up to 8 weeks.
  • For short term treatment of erosive esophagitis:
    • 30 mg once a day for up to 8 weeks.

PEDIATRIC DOSAGE (for 1 to 11 years of age):

  • For short-term treatment of symptoms of GERD and short-term treatment of erosive esophagitis:
    • Less than or equal to 30 kg body weight:
      • 15 mg once a day for up to 12 weeks.
    • 30 kg or more body weight:
      • 30 mg once a day for up to 12 weeks.

PEDIATRIC DOSAGE (for 1 to 11 years of age):

  • For short-term treatment of non-erosive GERD:
    • 15 mg once a day for up to 8 weeks.
  • For short-term treatment of erosive esophagitis:
    • 30 mg once a day for up to 8 weeks.
  • Maintenance of healing of erosive esophagitis:
    • 15 mg once a day.
  • For the treatment of Pathological Hypersecretory Conditions including Zollinger-Ellison syndrome:
    • 15 mg once a day.

GERIATRIC DOSE ADJUSTMENT:

  • No adjustments needed.

RENAL DOSE ADJUSTMENTS:

  • No adjustments needed.

HEPATIC DOSE ADJUSTMENT:

  • Consider dose adjustments in patients with severe hepatic impairment.

OVERDOSAGE:

  • No specific antidote is known.
  • Dialysis does not aid in excess drug removal as Lansoprazole is extensively protein bound.
  • Supportive treatment should be given as and when required.
  • Contact the emergency department of your local hospital in cases of overdose or suspected overdose.

Side effects or unwanted effects:

  • The most common adverse reaction is diarrhea.
    • Consult your doctor as soon as possible. This may require discontinuation of the treatment with lansoprazole.
  • Acute intestinal nephritis.
    • Fever, nausea, vomiting, skin rash, confusion, fatigue, exhaustion and blood in the urine are some of the symptoms. Consult your doctor as soon as possible.
  • Treatment with proton pump inhibitor may be associated with an increased risk of Clostridium difficile associated diarrhea, particularly in hospitalized patients.
  • Long time treatment with lansoprazole may increase the risk of osteoporosis related fractures of hip, wrist or spine.
  • Change of taste or a bad taste, acne, back pain and drowsiness was reported by patients taking Lansoprazole for a long period of time.
    • Ask your pharmacist to recommend a suitable medicine and consult your doctor.
  • Hypomagnesemia in patients taking proton pump inhibitors for over a year, characterized by arrhythmias, seizures and tetany.
    • Consult your doctor as soon as possible. This may require magnesium supplement and discontinuation of the proton pump inhibitor.

WARNINGS:

  • Treatment with proton pump inhibitor may be associated with an increased risk of Clostridium difficile associated diarrhea, particularly in hospitalized patients.
  • Long time treatment with lansoprazole may increase the risk of osteoporosis related fractures of hip, wrist or spine.
  • Contraindicated in patients with a known hypersensitivity to dexlansoprazole, lansoprazole or any of the content of the formulation.

Pregnancy:

Category B, which means that Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

  • No sufficient human studies have been conducted regarding the use of lansoprazole in pregnant women.
  • Lansoprazole should be used in pregnancy only if clearly needed or if no other options are available.

Nursing:

  • Data not available.
  • Caution should be exercised while administering lansoprazole to a nursing mother as many drugs are secreted in milk.
  • Caution should be exercised as many drugs are found to be secreted in human milk which causes unwanted exposure of the drug to infant and a potential for side effects associated with that drug.

Interactions

Drug interactions of lansoprazole:

  • Lansoprazole decreases gastric pH. Any drug, whose absorption is dependent on gastric pH, affects the absorption of that drug when co-administered with Lansoprazole.
    • Absorption of Ketoconazole, Atazanavir, Erlotinib, iron salts and mycophenolate mofetil is decreased while absorption of digoxin in increased.
  • Lansoprazole increases the concentration of Saquinavir.
  • Lansoprazole decreases the concentrations of Rilpivirine, Atazanavir and Nelfinavir.
    • Concomitant use of Lansoprazole with above mentioned drugs is contraindicated as such combination would decrease the efficacy of anti HIV treatment and may pose a risk of viral resistance.
  • Concomitant use of Lansoprazole and warfarin should be done under strict monitoring, particularly for the increases in INR and prothrombin time.
  • Concomitant use of lansoprazole and methotrexate may lead to increased and prolonged plasma concentration of methotrexate and/or its metabolite hydromethotrexate.
  • Concomitant use of Lansoprazole and theophylline may increase the clearance of theophylline.

Drug – food interactions:

  • Lansoprazole should be taken on empty stomach before meals.
  • Avoid alcohol with Lansoprazole as it may reduce the efficacy of Lansoprazole.

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Lansoprazole wikipedia page

Note: The sole purpose of every information shared on this article is to bring awareness. Do not use this information as a medical advice or prescription advice or as a tool for the treatment, diagnosis or prevention of the disease.

By |2018-12-29T07:06:16+00:00May 2nd, 2017|medicines|Comments Off on Lansoprazole

About the Author:

B. Pharm (K.L.E. society's S.V.V. Patil College of Pharmacy, Bengaluru) M. Pharm (Maharishi Arvind Institute of Pharmacy, Jaipur)

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